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Homeostasis, Glucose Metabolism, and...
Why Is It So Difficult To Be A Good Pancreas?
Deb Pierce and Robin Goldstein
Harvard Public Schools
We walked into an AP Biology class in early June to
pilot a lesson about glucose metabolism that we are hoping to use this year
with biology students. These AP students had already taken the AP exam in late
May. We knew they would need some encouragement to delve again into topics like
homeostasis (the ability of organisms to maintain internal equilibrium) and
glucose metabolism. We came to class armed with chocolate chip cookies, and an
apple for the one student in the class who is diabetic. He thanked us for being
thoughtful, but also informed us that there was no difference between eating an
apple and a cookie - they both contain sugar. He later explained the nuance of
difference - a cookie releases a faster and higher surge of glucose into the
blood than an apple. As we ate, the question was asked, "Why are we eating
cookies?" "Because they taste good," someone replied. We proceeded to ask them
what was happening in their bodies as they ate their cookies.
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Deb Pierce has been a Biology teacher at the Bromfield School in
Harvard, MA for 14 years teaching biology and AP Biology. Her teaching
experience spans 21 years. In addition to teaching, Deb is the secretary of the
Massachusetts Association of Biology Teachers and served as an AP Bio exam
reader.
Deb's e-mail: djp122654@aol.com
Robin Goldstein has been teaching for a total of 15 years, 11 years of middle
school science and 4 years of systems thinking mentoring with the Waters
Foundation.
Robin's e-mail: robinsailgo@att.net
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Using causal loop diagrams and stock/flow mapping we
discussed the homeostatic controls that were taking place in their bodies (or
being considered with some blood glucose testing and an insulin injection) as
they ate.
Students then moved to computers, working in pairs using a STELLA
model to see the effect of different glucose release rates on insulin
secretion. When given the opportunity, they tried to see what level of glucose
release over time the body could tolerate by keeping glucose release
consistently high - the equivalent of consuming several cans of JOLT over a
couple of hours. They were impressed with the body's ability to keep up. Once
the role of the pancreas shifted to students, they developed a newfound
reverence for the organ. "I wouldn't make a very good pancreas," one student
remarked. The delicate balancing feedback system, imbued with delays, that
exists to preserve homeostatic levels of insulin and glucose was becoming
clearer to students. What crystallized this vision for them was comparing a
healthy system to that of a diabetic. Here students were determining how much
insulin is needed for a "patient" before a food is ingested. For example, if a
diabetic patient wanted to eat an apple, and the apple contains a given amount
of glucose, how much insulin should be taken prior to eating the apple? It was
difficult enough for them to find the optimal level and injection rate of
insulin when a diabetic was releasing glucose into the blood at a constant rate
(which supports the diet recommendation that diabetics eat many small meals
throughout the day instead of the cursory three). Once the diabetic was
releasing glucose into the blood at varying rates over time, it became an
arduous task to maintain homeostasis. Students were seeing how critical each
adjustment is to maintain normal blood sugar in a person who has no built-in
mechanism to control blood sugar. What we didn't have time for, but plan to
include next year, is a final challenge for students: to develop an insulin
pump that can continuously secrete insulin (like the pancreas), responding to
ebbs and flows in glucose levels to more consistently maintain homeostatic
levels of insulin and glucose than periodic injections of insulin.
Homeostasis is an abstract concept that some students have a difficult time
visualizing. STELLA modeling provides a hands-on realistic manipulative
that allows students to experience negative feedback and so homeostatic control
mechanisms. Used as an introduction to homeostatic feedback mechanisms, STELLA
modeling provides students with an enhanced level of understanding upon which
teachers can build.
The original models were developed by Matthew C. Halbower, Rebecca D. Niles,
and Tad T. Sudnick of the MIT Pre-College Education Project; three years later
an interface for these models was created by Will Glass-Husain of the Catalina
Foothills School District in Tucson,AZ. I also added to the models on my own
and modified the interface I used with students. The original model and lesson
plan documents are on the Creative Learning Exchange website.
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